Giants-Yankees preview: Bumgarner, Paxton set to square off

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first_imgSAN FRANCISCO — It doesn’t matter where they go or who they’ve got, the New York Yankees always draw a crowd.That should remain true this weekend as the Bronx Bombers visit Oracle Park for the first time since 2007. The Yankees have a national audience, but even their most devoted followers may not know the names of the team’s starting nine.Fifteen different players have landed on the Yankees’ injured list this season, an astronomical number that includes power hitters like Aaron Judge and …last_img


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first_img(Visited 59 times, 1 visits today)FacebookTwitterPinterestSave分享0 Success with rabbits and with children offers promising cures for blindness in humans, using ethical stem cells.The headlines are really eye-grabbing:Vision restored in rabbits following stem cell transplantation (Science Daily).Eye Lenses Regenerated Using Infants’ Own Stem Cells (Live Science).Stem cells regenerate human lens after cataract surgery, restoring vision (Science Daily): “Approach may have broad therapeutic implications on tissue and organ repair.”The results from international teams publishing in Nature are truly spectacular. Live Science says,They found that the infants’ incisions healed within one month, and the transparency of their line of vision was more than 20 times better, compared to infants with congenital cataracts who received the current, standard treatment.The finding shows that “we can harness our own stem cells to regenerate a tissue or organ,” Dr. Kang Zhang, who led the study and is an ophthalmologist at the University of California, San Diego, told Live Science.Another benefit is that the stem cells are already there. They just need to be removed, nursed, and re-inserted. Science Daily says,Unlike other stem cell approaches that involve creating stem cells in the lab and introducing them back into the patient, with potential hurdles like pathogen transmission and immune rejection, endogenous stem cells are stem cells already naturally in place at the site of the injury or problem. In the case of the human eye, lens epithelial stem cells or LECs generate replacement lens cells throughout a person’s life, though production declines with age.In a similar development, Japanese researchers also reporting in Nature have found a way to use induced pluripotent stem cells (iPSCs) to restore the cornea. Julie T. Daniels summarizes these “visionary stem cell therapies” in a companion piece in Nature. A diagram in her article shows how the insertion of these stem cells repairs the real lens and cornea of patients. Current treatments for cataracts remove the living lens for an artificial one. The new way is like turning back the clock and letting the body develop the eye the way it was meant to be.Incidentally, PhysOrg reports that a “novel reprogramming factor yields [a] more efficient induction of human pluripotent stem cells,” meaning that it’s getting easier to deliver the goods to the surgeon. Adding to the celebration, Science Daily reports on a new drug that can return stem cells to their embryonic state.Who needs embryonic stem cells?This is great news, and more may be coming. We’ve already seen rapid advances with adult stem cells and iPS cells. The finding that our own eyes have the cells needed to repair a lens or cornea suggests that the original creation was outfitted for regeneration, but those abilities have degenerated since. Whether or not that is the case, the cure for blindness may have been staring us in the eye.last_img read more


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first_imgA recipe is a process. It tells you, step-by-step, what you need to do to get a certain outcome. If you are baking a cake, a recipe takes you from start to finish, covering all the steps in between.A sales process takes you from target to close, covering all of the steps along the way. It tells you how to target the right prospects. It gives you directions on how best to qualify your prospects. It provides you with the steps you need to take to uncover your client’s needs and requirements. It gives you guidance on how to present your solution and give evidence. It gives you the steps to acquire the account, to negotiate, and to close the business. A sales process is end to end.A sales methodology is different. It’s a recipe, too, but it’s a different kind of recipe. It’s more like a recipe for icing, not a cake. A recipe for icing can bolt right onto your recipe for cake, just like a sales methodology bolts onto a sales process.A sales methodology gives you the steps for some part of a sales process. The best way to demonstrate this is with an example. Let’s use Neil Rackham’s SPIN Selling. Rackham’s methodology is a system for asking questions. It’s still pound-for-pound the best methodology for asking questions in sales. But it isn’t a sales process. It can be used within any sales process.My friend Jill Konrath wrote a tremendous book called SNAP Selling. It doesn’t really matter what sales process you use, Jill’s methodology is about getting in, being relevant, being invaluable, and aligning what you do with your client’s priorities. You can read her book and get help with these sales challenges regardless of your company’s sales process.Too Much Icing, Too Little CakeIt’s possible to eat only icing. But it’s really not supposed to be eaten alone. It’s not a substitute for the cake. It’s supposed to help make the cake better.It’s important not to confuse sales processes and methodologies. You need a sales process. You can enhance them by adding some methodologies. But you can’t substitute a methodology for a sales process; it leaves too much out.QuestionsDo you have a sale process, or do you really use only a methodology?What are the benefits of having an end-to-end process to guide you from target to close?If you subscribe to some methodology, what parts of the common sales process does it cover? What parts is your methodology missing?If you have a sales process, what methodologies have you bolted on to give you a philosophy or a system for some parts of that process? Essential Reading! Get my 3rd book: Eat Their Lunch “The first ever playbook for B2B salespeople on how to win clients and customers who are already being serviced by your competition.” Buy Nowlast_img read more