Evening Newswrap May 27

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first_imgSabzar Ahmad Bhat killing: Internet services suspended in Kashmir, stone pelting in some areasWithin 24 hours of lifting a ban placed on internet services in the Valley, the Jammu and Kashmir government has restricted websites yet again. The move follows the killing of Sabzar Ahmad Bhat in an encounter in Tral.Rahane confident India ready for ICC Champions TrophyDefending champions India will start their Champions Trophy campaign against arch-rivals Pakistan on June 4 at Edgbaston.Sachin A Billion Dreams box-office collection: The sports docudrama does well on FridaySachin A Billion Dreams had a splendid box-office opening on Friday. Meanwhile, Hindi Medium is still going strong at the box office unlike Half Girlfriend. Sri Lanka appeals to UN to help after landslides, floods kill over 100, displace 2,900Rain-triggered landslide and floods in Sri Lanka have claimed up to 100 lives, leaving scores injured and over 99 missing. The Indian government has offered assistance in rescue and relief operation, with three Navy ships dispatched for help.last_img read more


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first_imgEditor’s note: This is the fifth in a 15-part series in which we preview college football’s top teams. We’ll be counting down from 15 to one, with the final team, released on Sept. 3 – the day college football starts – serving as our national title pick. 11. Clemson TigersThe Clemson Tigers are a trendy pick to win the ACC this year, despite the fact that Florida State is the three-time defending conference champion. Clemson has won at least 10 games in each of the past four seasons, and many believe that if star quarterback Deshaun Watson can stay healthy all year, the Tigers will have a legitimate shot at taking the next step and competing for a national championship. The program finished on a high note in 2014, blowing out Oklahoma, 40-6, in the Russell Athletic Bowl. Can they keep it rolling into 2015?Clemson kicked off practice just a few days ago. The school has been releasing footage all week.#PAWDrill is back! #Clemson pic.twitter.com/ObxgSOlwt1— Clemson Football (@ClemsonFB) August 10, 2015Not everyone thinks the Tigers have what it takes to win it all, though.Where They’re At In The RankingsUSA TODAY Coaches’ Poll – No. 12ESPN FPI – No. 19Las Vegas odds – No. 20The Schedule Clemson Russell Athletic Bowl RingsTwitter/ClemsonSept. 5 – vs. WoffordSept. 12 – vs. Appalachian StateSept. 17 – at LouisvilleOct. 3 – vs. No. 11 Notre DameOct. 10 – vs. No. 17 Georgia TechOct. 17 – vs. Boston CollegeOct. 24 – at Miami (FL)Oct. 31 – at NC StateNov. 7 – vs. No. 8 Florida StateNov. 14 – at SyracuseNov. 21 – vs. Wake ForestNov. 28 – at South Carolina Key GamesOct. 3 vs. Notre DameClemson gets its first real test at Louisville on a Thursday night in September, but there’s no doubt that Tigers fans have had Notre Dame circled on their 2015 schedule for years. The Irish and Tigers are both considered national title hopefuls, and assuming both have unblemished records heading into the contest, the winner is going to have a leg up for the College Football Playoff rankings. Notre Dame’s defense struggled down the stretch last year, and assuming Watson is still on the field for the Tigers, they’ll have a decent shot at knocking off the historic program. It’ll also be interesting to see how new Fighting Irish starter Malik Zaire deals with Clemson’s likely-formidable secondary. Nov. 7 vs. Florida StateFor as successful as Clemson has been over the past three years, the Tigers still haven’t been able to crack Florida State. In 2015, former Heisman Trophy winner Jameis Winston (who went No. 1 overall to the Tampa Bay Buccaneers) is gone, and the Seminoles will (most likely) rely on Notre Dame transfer Everett Golson to lead the charge. That being said, Clemson lost at home last year, 23-17, with FSU sporting backup Sean Maguire. If Clemson wants to get serious about finding itself in the College Football Playoff, they’ll have to take care of the Seminoles to get there.Nov. 28 at South CarolinaYes, Clemson vs. South Carolina is still just a non-conference game. But even if both schools were 0-11 heading into it, it would still be the most important contest on the schedule. The in-state rivalry between the two, now dubbed The Palmetto Bowl, is one of the best in the sport. The war of words between Dabo Swinney and Steve Spurrier isn’t too bad, either.Key PlayersDeshaun Watson, sophomore quarterbackWatson had a very bizarre freshman season. Back in April, he broke his collarbone. He started the season as the backup to Cole Stoudt, and after performing very well against Florida State in relief, he was named the team’s starter. A few weeks later, he broke his finger against Louisville and was out of action until mid-November. In returning against Georgia Tech, he tore his ACL. After sitting out against Georgia State, he returned for the team’s rivalry game with South Carolina, and led the Tigers to victory, despite the injury. He then shut it down, opting to have surgery instead of playing against Oklahoma. Got all that?When Watson was on the field, Clemson was a much more efficient team. He threw for 1,466 yards, 14 touchdowns and two interceptions in limited work. He also rushed for 200 yards on 63 attempts. He’s a player single-handedly capable of winning Clemson the conference title. But can he stay healthy?I knew my time was coming, I just had to wait for it. So every night I prayed for opportunities like this. Time to go LIVE it! #WishMeWell— Deshaun Watson (@ShaunWatson4) August 4, 2015Shaq Lawson, junior defensive endClemson boasted one of the country’s top defenses in 2014, but ahead of the 2015 campaign, the Tigers will have to replace eight starters. Lawson, a 6-foot-3, 275-pound stud defensive end, should help to ease that burden. He’s one of the best at his position in the ACC. If the Tigers are going to hang their hat on defense again this year, he’ll have to be a menace.Lawson was a Freshman All-American in 2013, and last year, he recorded 44 tackles, including 11 for loss. If he’s able to continue improving, he’ll be one of the most feared players in the country.It’s time to seperate the good from the great. Until January social media… It’s time to go to work boys.— Shaq Lawson (@Shaq_Lawson90) August 4, 2015Wayne Gallman, sophomore running backDespite winning 10 games in 2014, Clemson struggled running the football. In fact, the Tigers finished 81st in rushing offense, averaging just 3.5 yards per attempt. Much of that was because Cole Stoudt, who isn’t an overly athletic signal-caller, was on the field a good portion of the year. But the team’s running backs didn’t put up staggering numbers either. The longest run from scrimmage was only 34 yards – by Wayne Gallman. Gallman, who led the team in both carries (161) and yards (769) last season, will need to improve in his sophomore year. Clemson will need to have a strong running game to compete this year – especially if Watson ever catches the injury bug again.twitter see yall in January. #doakseason pic.twitter.com/6iFngorvX8— Wayne Gallman II (@Wanye_Kanye) August 4, 2015 Why They Can Win The National TitleClemson returns just 11 starters from last year’s team, so it’s possible that the Tigers are a year or two away from competing for a national championship. The squad may not have the defense it had a year ago, given the departures of Vic Beasley, Stephone Anthony and Tony Steward, but head coach Dabo Swinney does seem to have confidence in this year’s unit. If he’s right, Clemson will be formidable.The other major factor, obviously, is Watson’s health. If he can stay on the field, Clemson will be very difficult to stop. But the second he’s sidelined, the Tigers will either be relying on junior Nick Schuessler, who has attempted 10 passes in his career, or a true freshman with zero experience. Every time Watson goes down, Tigers fans will collectively be holding their breath.Regardless, Clemson’s program seems to be in a good place. If everything falls right in 2015, the Tigers could have a special year.Yesterday: No. 12 LSU; up tomorrow: No. 10 Florida Statelast_img read more


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first_imgOTTAWA – Parliamentary budget officer Jean-Denis Frechette’s latest report on the Liberal government’s infrastructure spending program highlights further delays in the spending plan. Here are some key numbers from the report:$186.7 billion: Value of federal infrastructure spending over 12 years$14.4 billion: Value of spending under the first phase of the infrastructure program32: Federal organizations responsible for Phase 1 of infrastructure spending10,052: Projects identified by the PBO report, which qualified the total by saying it is not a full inventory of Phase 1 projects$7.2 billion: Value of those projects, about half of the total planned spending8,800: Projects approved in fiscal year 2016-171,300: Projects approved in fiscal year 2017-181,667: Approved projects that to do not have a federal contribution identified6,000: Projects with identifiable start dates1,300: Projects that are scheduled to begin after 20180.1: Per cent increase in GDP in each of the two fiscal years covered in the report11,100: Maximum estimated number of jobs federal infrastructure spending has created between April 2017 and March 2018last_img read more


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Basketball player Carmelo Anthony says playing with Amar’e Stoudemire was “one of the reasons I wanted to come to New York.”Now that his Knicks teammate is struggling with another knee injury, Anthony is having a difficult time watching Stoudemire go through the agony of recovery.“As a friend, it’s hard for me to sit back and act like it doesn’t bother me because I know how hard of a worker he is [and] I know the time that he puts in the gym to train and rehab,” Anthony said Tuesday. “To see him go forward and then take some steps back every time, it’s just sad.”According to reports, Stoudemire will miss the Knicks’ first three preseason games. Stoudemire is rehabbing from knee surgery he received over the summer, his third in the past year.“I’m still getting stronger, still getting the legs strong enough to withstand the pressure of playing, but progress has been great so far,” Stoudemire said.The 11-year veteran only played 29 regular season games in 2012-13, when he also had two separate knee procedures. read more


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Each member of the line must be on the ice for a goal to qualifySource: Left Wing Lock CGYJ. GaudreauS. MonahanM. Ferland251267.6 Goals BOSB. MarchandP. BergeronD. Pastrnak21387.5% TORZ. HymanA. MatthewsW. Nylander24972.7 COLG. LandeskogN. MacKinnonM. Rantanen291467.4 NYIA. LeeJ. TavaresJ. Bailey241955.8 The best among the best lines in the NHLThe top 10 lines in the NHL in goals scored while playing 5-on-5, by percentage of goals for TMLeft wingCenterright wingForVS.For % PHIC. GirouxS. CouturierJ. Voracek231069.7 For the first couple months of the season, the Boston Bruins had more problems than they could handle. They had lost more games than they had won. They were firmly out of the playoff picture. Top-line center Patrice Bergeron and his linemate Brad Marchand had both missed time with injuries. So had second-line center David Krejci. Goalie Tuukka Rask was a husk of his former self, and looked for a moment as though he might lose his starting job. Matt Beleskey, who the Bruins decided to pay $19 million because he had a handful of good weeks during the spring of 2015, had been placed on waivers.1He cleared them and now plays for Boston’s AHL affiliate in Providence.This was a team that had won the Presidents’ Trophy as recently as 2013-14, and that had a core made up of several skaters who’d played in two of the past seven Stanley Cup Finals. This was also a team that had failed to qualify for two of the past three postseasons, and that hadn’t won a playoff series since they beat the Detroit Red Wings in the spring of 2014.But since a loss to the Washington Capitals in mid-December, the Bruins have been damn near untouchable: They are 14-0-4 in their last 18 games. The Bruins looked like basement dwellers a few months ago, and now pundits are wondering whether they’re legitimate Stanley Cup contenders. But are they for real, or is this streak just a tantalizing aberration?The Bruins are a balanced hockey team — seven skaters have at least 25 points — but much of their recent form can be attributed to the extraordinary play of a rejuvenated Rask and the top line of Bergeron, Marchand, and David Pastrnak, which has established itself as one of the best in the NHL.In his last 18 starts, Rask has lost exactly zero games in regulation; in his prior 13 starts, he had won just three. During his recent dominant stretch, Rask has stopped 94 percent of the shots he’s faced; during his disastrous stretch, he stopped just under 90 percent of the shots he faced.2Not what you’d expect from the NHL’s all-time leader in save percentage.Goaltender play is notoriously unstable, so these gulfs in Rask’s performance aren’t actually as shocking as they seem on the surface. Even if Rask’s save percentage regresses and he stops roughly 92 percent of the shots he faces for the rest of the season, the Bruins will be in good shape.To explain the dominance of Marchand, Bergeron, and Pastrnak, the best place to start is their possession numbers. Bergeron is yet again among the league’s elite faceoff takers, winning more than 57 percent of his draws.3That number drops a bit to roughly 53 percent on power play draws, but Bergeron can be forgiven — unless he’s the man in the penalty box, teams often task their best faceoff man with taking draws on the penalty kill. Among qualifying skaters, all three on Boston’s top line rank in the top 50 in Corsi percentage,4Adjusted for score, zone and venue. which estimates a player’s possession rate by measuring the percentage of shot attempts directed at his opponent’s net versus his own net while he’s on the ice. And because the Bruins’ top troika are sending so many shots toward their opponents’ nets, all three also rank in the top 15 for goals per 60 minutes.Among lines that qualify, only 11 others in the NHL have a higher combined shooting percentage than the combination of Marchand, Bergeron, and Pastrnak. And their goals for percentage — which takes the total number of goals scored while a line is on the ice together and calculates the percentage of those goals that were goals scored by the line — is by far the best in the league. LOSA. IafalloA. KopitarD. Brown201360.6 TBLV. NamestnikovS. StamkosN. Kucherov261957.8 DALJ. BennT. SeguinA. Radulov201360.6 VGKR. SmithW. KarlssonJ. Marchessault321666.7 None of this is to say the Bruins are a one-line team — they’re far from it. Rookie forwards Danton Heinen and Jake DeBrusk have already chipped in with 11 goals each, and rookie defenseman Charlie McAvoy5McAvoy recently underwent minor surgery to correct an abnormal heart rhythm, but is expected to return in two weeks. is building a solid case for the Calder Memorial Trophy. And David Krejci is a pretty decent second line center, too: He’s scored 24 points in 29 games, and he’s winning 56.3 percent of his faceoffs, by far the best mark of his career.Boston will lose in regulation again — Marchand, who is serving a five-game suspension, and McAvoy’s temporary absences should ensure this happens sooner than later. But there’s nothing in recent memory suggesting Boston’s top line will cease to be a possession beast any time soon.6All three forwards finished in the top ten in Corsi percentage in 2016-17. If they keep getting (and burying) their chances — and if Rask’s ascendancy holds up, which his dazzling career implies it might — the Bruins might find themselves playing hockey in June again. read more


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first_imgLeicester City manager Claude Puel has confirmed that Jonny Evans is fit and will be in the matchday squad for Saturday’s trip to Wolves.A toe injury sidelined Jonny Evans for Leicester’s 2-1 home defeat to Southampton last weekend.But according to Leicester boss Claude Puel, the defender will be available for selection as they prepare to travel to Wolves for Saturday’s clash.“Evans can come back in the squad, it was not a serious injury,” Puel told the club’s website during Thursday’s pre-match press conference.Harry Maguire, Manchester UnitedLiverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.“He will be in the squad on Saturday. Of course, I am happy when a player can come back in the squad.”Leicester will be without Daniel Amartey who is still nursing an ankle injury he sustained in their 1-1 draw with West Ham in October.As they go in search of their first win in three Premier League matches, the foxes have no other injury concerns aside from Amartey.last_img read more


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first_imgParis Saint-Germain will play against Saint-Etienne later tonight as the team hopes to maintain their good run.Paris Saint-Germain is looking for its 20th victory of the 2018-2019 French Ligue 1 season.PSG will face Saint-Etienne tonight as the team comes from beating Manchester United at home in the UEFA Champions League.“Thomas Meunier will be missing tomorrow, Choupo-Moting is ill. He trained with us yesterday, but today he’s resting,” manager Thomas Tuchel explained to the team’s official website.“All the others should be available, we’ll wait until the end of the training session for the some of them. Neymar and Cavani are out.”“We’ll be cautious with those who have played a lot and those who have only just come back from an injury like Marco Verratti and Presnel Kimpembe,” he added.“They’re a very strong team that has done rather well against the league’s big teams, against the top five.”“They have experience and a lot of quality. We also know that the atmosphere at Saint-Étienne is great, and it’ll be a big challenge for us to play them at this stage of the season,” he commented.“When you’re at Paris Saint-Germain, you have to expect these kinds of games, you have to be ready and well prepared for each game because teams are waiting for us,” Tuchel added.Opinion: Neymar needs to apologize to PSG’s supporters Tomás Pavel Ibarra Meda – September 14, 2019 After such a dramatic summer during the transfer window, Neymar truly needs to apologize to all the PSG supporters this weekend.When Neymar finished last…“We have had two days off and two to prepare well. We’ll have to play to our best if we want to win at Saint-Étienne.”“At a club like Paris Saint-Germain, you always have to show that will to win, because we want to win everything. The players who are here want to play and win too,” the PSG boss added.“No-one at the club, whether it be the players or the staff, looks at the fixture list and considers this or that match more or less important.”“We are here to achieve objectives and we have to prove ourselves up to the task, every day. We have to be ready to take on any challenge that crosses our path,” he concluded.Good morning @DaniAlvesD2 ☀️✈️ @ASSEofficiel #goodcrazy #ASSEPSG pic.twitter.com/BO5MIIAnDr— Paris Saint-Germain (@PSG_English) February 17, 2019last_img read more


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first_img Bi-lateral talks with Bahamas to resume, UK gives green light to high-level TCI delegation Recommended for you Facebook Twitter Google+LinkedInPinterestWhatsAppBahamas, 25 Jan 2015 (Ministry of Finance Press Release -Bahamas)- The Government has completed the appointment of members of the VAT Appeal Commission. The names which will be unveiled this week, include a retired Supreme Court Justice as Chairman, a retired senior Customs officer and a public accountant. These individuals will also serve as members of the Customs Appeal Commission.The VAT Appeal Commission will operate independently of the VAT Department and the Ministry of Finance.If a VAT registrant is unhappy with any decision made by the VAT Comptroller, they may lodge an appeal with the Commission. An appellant who is aggrieved by a decision of the Commission may appeal the decision, but on matters of law only, to the Supreme Court.The timing of the appointment of the Commission is critical at this juncture, as enforcement activities and rulings of the VAT Department become more entrenched. The appointments are with effect from January 21, 2015. Hurricane Jose Not A Threat to The Bahamas, For Now Bahamian music legend gunned down at home in Turks and Caicos Related Items:appeal, bahamas, ministry of finance, vat Facebook Twitter Google+LinkedInPinterestWhatsApplast_img read more


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first_img Historic scholarships awarded by Latin GRAMMY Cultural Foundation Historic scholarships from Latin GRAMMY Foundation historic-scholarships-awarded-latin-grammy-cultural-foundation News Twitter Facebook Record-setting amounts awarded to select music students around the world by the Latin GRAMMY Cultural FoundationBrian HaackGRAMMYs Jul 28, 2017 – 1:24 pm GRAMMY.comThe Latin GRAMMY Cultural Foundation’s charitable support for music education programs around the world has topped more than $2.5 million in just the few short years since the Foundation launched in 2015.However, just this week, the Foundation has announced its largest-ever series of scholarship awards for a single year, with a whopping $870,000 being awarded to 44 select Latin music students from around the world.The monies include the Foundation’s yearly flagship Miguel Bosé Scholarship, which this year will provide $200,000 in tuition support for 22-year-old Dominican electric bassist Ernesto Núñez, who will be entering Berklee College of Music this fall to study contemporary writing and production.Additional Gifted Tuition Scholarship awards were presented to Andres Guerra, 21, a classical guitarist from Venezuela; Nikola Vasiljevic, 17, a Dominican bassist; and Carolina Mercado, 22, a tenor saxophonist from Mexico, in the amounts of up to $100,000 for each student.Guerra and Vasilijevic will each be attending Berklee, while Mercado will attend the School Of Jazz at New York City’s prestigious The New School.Rounding out the distribution, 40 additional students attending various schools in Colombia, Mexica, and Spain will also receive Tuition Assistance Scholarship grants of up to $10,000 each.”Thanks to our generous donors, involved artists, and compassionate partners, we continue to be in a strong position to provide support to truly talented Latin music students in need and with the tools to pursue their dreams to follow in the footsteps of their Latin music icons,” Said Manolo Díaz, Senior Vice President of the Latin GRAMMY Cultural Foundation.Alejandro Sanz named 2017 Latin Recording Academy Person of the Year Email last_img read more


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first_imgSUDBURY, MA — Retired Naval Commander Harold D. Homefield, PhD, passed away Friday night, December 28, 2018. Born March 22, 1919 Dr. Homefield was 99 years old. He was an accomplished educator, speech therapist, and Naval officer.Commander Homefield volunteered to join the Navy in WWII, starting active duty immediately after graduating from college. One of the “90-day wonders,” Harold was promoted rapidly and served most of his tour as commander of the USS Phenakite, a yacht converted to anti-submarine patrol craft. After the war, Lt. Homefield joined the Naval Reserve, eventually retiring holding the rank of Commander.Dr. Homefield was determined to earn his PhD in speech therapy, which he did over years of exceptional scholarship at NYU, while working at several jobs to support his family. His commitment to education led to numerous academic positions including Principal of Pelham HS in New York and Assistant Superintendent of Schools in Wilmington MA. He also taught speech at Pace College and treated individual speech impaired individuals.Harold was married to Edith Beer in 1942. Edith passed in May of this year. They are survived by their three children, Joan, Brenda and Roger. Harold was the grandfather of six children and the great-grandfather of eight. He enjoyed sharing his history with his beloved family and participating in family gatherings.Around Sudbury, he was well known and much liked by town officials and business personnel. He was awarded the Boston Post Cane in 2015 where he gave a charming address at age 96. Harold recorded an engaging interview as part of the Natick Veterans Oral History Project, providing anecdotal insights into his life and times.Friends and relatives gathered for a graveside service in Sharon Memorial Park, Sharon, on Sunday, December 30, 2018, at 2:45 PM. Arrangements were handled by Duckett-J.S. Waterman Funeral Home, 656 Boston Post Road, SUDBURY, MA 01776.Harold Homefield(NOTE: The above obituary is from Duckett-J.S. Waterman Funeral Home.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedOBITUARY: James Thayer Hastings, 84In “Obituaries”OBITUARY: Michael Joseph Kelley, 60In “Obituaries”OBITUARY: Hobart W. Spring, Jr., 88In “Obituaries”last_img read more


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first_imgBTRCBangladesh Telecommunication Regulatory Commission (BTRC) is going to deactivate additional SIMs of those who have more than 15 against one national identity (NID) card from early Friday, reports UNB.The telecom regulator has identified a total of 2049,927 such SIM cards and those will be deactivated within six hours after 12:00am, BTRC senior director Jakir Hossain Khan told UNB on Thursday.As per the latest BTRC decision, a subscriber is allowed to register maximum 15 SIM cards against his/her NID card.BTRC chairman Md Jahurul Haque said this move will ensure subscriber-friendly services and bring discipline in the telecom sector, expressing the hope that people will be able to receive better telecommunication services without any hindrance.On 20 June, 2016, BTRC fixed 20 SIMs to be registered against one NID card and later it reduced the number to five on August, 2017.On October 24, 2017, the commission revised its decision and set the number at 15.A subscriber can know how many SIM cards have been registered against his/her NID by dialing *16001# or by sending a SMS to 16001 typing the last four digits of the NID card.last_img read more


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first_img X Share Listen Harris Health had a rough year, but it looks a lot better now that it’s over. At the start of the fiscal year that that began last March, board members and executives faced a projected deficit of more than $70 million.“That was the result of what we call ‘the perfect storm,’ explained President and CEO George Masi. “Increased patient volumes, no expansion of Medicaid in Texas — and that had a profound effect on Harris Health — and just the inflationary factors associated with healthcare.”To cope, managers stopped filling vacancies, eliminated raises for most workers, and laid off almost 100 people. The personnel changes alone saved almost $17 million.Masi said it was painful to do: “These were real people, doing real jobs, with real work.”Managers also found savings in pharmacy, laboratory and supply chain costs.Masi says strategic streamlining also helped save money. For example, Harris Health is so overwhelmed with cases that managers had been paying other hospitals to perform certain surgeries on its patients. But it stopped that outsourcing last year, and saved more than $7 million from those contracts.“These are not emergent cases, these are cases like a gallbladder, maybe a hernia repair that could wait, sometimes wait inordinately long times, to be managed,” Masi said.“But we pulled those all back in, and actually just expanded our hours, worked harder, pushed the staff a great deal to get that done, and they did,” he added.  Finally, just a few weeks ago, there was what Masi calls a “February Christmas present” — $14 million more in tax revenues than expected.That eliminated the budget hole, with $1.1 million left over.“It’s like the little train that could,” Masi said. “There are not a whole lot of people who thought we could make up that kind of ground. It was a lot of sacrifice, on the part of a lot of folks associated with the organization, that allowed us to make that margin.”But the pressure isn’t off yet.This fiscal year, Masi faces a new deficit of $8 million. Even if he overcomes that, he’s not able to save and recapitalize for maintenance, new equipment and growth, he said. Too many years in that state are not sustainable, he said, and so he will continue to push Texas politicians to expand Medicaid using federal dollars. To embed this piece of audio in your site, please use this code: 00:00 /01:38last_img read more


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first_img Share DALLAS (AP) — The Latest on reports of shots fired at Dallas Love Field airport (all times local):Officials say that when a police officer opened fire outside a Dallas airport on a man involved in a domestic disturbance, one bullet hit an exterior glass wall and the rest hit the suspect.Officials said they didn’t know yet how many bullets were fired Friday. In video posted by Instagram user @flashyfilms— and credited to Bryan Armstrong, at least nine gunshots could be heard.Dallas police Sgt. Mike Beattie, who is stationed at Love Field, says that the bullet that hit the glass wall outside the airport’s baggage claim area didn’t penetrate it because of the protective film.The condition of the man shot was unclear, however one officer at the scene, who would not be named, said he was told that the victim “absorbed” all the other bullets.Beattie says airport police receive specific training to be attentive to suspicious-looking travelers and that DPD provides “crowded-environment training” to all its officers every two years.last_img read more


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first_imgKolkata: Miscreants tried to extort money from acquaintances of a doctor after hacking his e-mail ID. On November 12 around 4:20 pm, the ID was hacked and a mail was sent. It was found that several people had received thesame mail. The Head of the Department (HOD) of Oncology department at Calcutta Medical College and Hospital, Dr Shibashis Bhattacharya alleged that on November 12 he got a phone call from one of his friends claiming that he sent a mail saying he is in danger and in need of Rs 40,000. Also Read – Rain batters Kolkata, cripples normal lifeOn hearing this, Bhattacharya suspected his e-mail account was hacked. He immediately rushed to a cyber cafe and changed the password. But that did not help. A few hours later, the same mail was sent to another person close to Bhattacharya. It read: ‘I hope you’re doing okay and this e-mail finds you well. Please where are you at the moment? I’m having such a frustrating ordeal right now and need an urgent favor from you. I’m unavailable over the phone, so I will appreciate if you could email me back as soon as you get this.’ Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedWhen the recipient replied through e-mail he was asked to transfer Rs 40,000 to one bank account. It was also mentioned that Bhattacharya was out of town and the money is urgently needed for a person’s surgery close to him. As he is out of the town, he is asking him to provide the money. Everyone found the matter to be fishy and did not tranfer the money. When Bhattacharya came to know that several people in his circle had received the same mail, he lodged a complaint with Cyber Crime Cell in Lalbazar. “I lodged a complaint with the police. They told me that sleuths are probing in to the matter. Thankfully nobody transferred the money to the account otherwise it would have been a disaster,” said Bhattacharya.last_img read more


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first_img Growing a business sometimes requires thinking outside the box. Special Report: Record BreakersMeet the entrepreneurs who are reinventing the music business. The Flaming Lips’ Wayne Coyne Takes a Leading Role Reinventing the Music IndustryCarving a Niche in Digital Music DistributionAn Innovative Recording Studio Goes MobileA Record Label Mines the Past for Music Aficionados and CollectorsThe Dusty Groove America Record Store Keeps on SpinningIf the founders of online jukebox service Rdio (pronounced ar-dee-oh) are right, the concept of an individual music collection is a thing of the past. “Look at what’s happened with Netflix,” says Rdio CEO Drew Larner. “The same shift is going to happen in music–and faster.” The future of music is streaming, Larner says, thanks to faster broadband access, the proliferation of smartphones and consumer acceptance of on-demand content.Founded in 2010, Rdio joins other music streaming services (Rhapsody, MOG, Apple and Pandora, to name a few), but adds a twist: The service is built around a social experience that helps consumers discover music organically. They “follow” friends and influencers and get a live network activity feed, and they share playlists on Facebook and Twitter–which features an embedded Rdio player in its user interface when you click on an @Rdio link. (There’s an API for developers.)Rdio founders Niklas Zennström and Janus Friis certainly are no strangers to the game-changing nature of the internet. They previously founded the phone-busting service Skype, the online video service Joost and–how’s this for irony?–the Napster-like music-sharing service Kazaa.A subscription ($4.99 a month for web only; $9.99 a month for mobile and web) gets you unlimited access to a constantly expanding catalog–currently around 10 million songs–that includes everything from the latest Lady Gaga release to the Flaming Lips’ live radio session of “Yoshimi Battles the Pink Robots Part 1.” Users can play whole albums and artist-related radio stations, create set playlists and add songs to a virtual music “collection,” queue songs for offline playback and, best of all, see what everyone else is listening to. Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global This story appears in the May 2011 issue of . Subscribe » In February, Rdio closed on a $17.5 million investment round, prompting Larner to move from L.A. to headquarters in San Francisco (and throw out about 500 old albums in the process) to head up the next stage of expansion: refining the service, launching in more countries, building up partnerships and hiring up to 15 new employees by the end of the second quarter (there are 35 now, plus a Boston terrier named Duke).In Demand: Rdio CEO Drew Larner, far left, with VPS Todd Berman and Malthe Sigurdsson.”We’re in discussions with everyone–labels, internet service providers, handheld manufacturers, celebrities–you name it,” he says. “The music industry needs a low-cost streaming service as a discovery mechanism that leads to album and ticket sales, and Rdio is a good first step in that direction.”Of course, the main hurdle is getting people to change their consumption patterns from ownership to a pay-for-access model. Based on the subscription numbers since its launch last August, though, Larner thinks Rdio can break more than 1 million subscribers within the next five years, becoming a serious industry player.But first, he has to move again. Rdio is going to need a much bigger office.center_img 3 min read April 26, 2011 Register Now »last_img read more


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first_img Dan Steinhart Managing Editor of The Casey Report Dear Reader, Casey Research Chief Economist Bud Conrad joins us today to analyze what’s behind gold’s recent weak performance. As is his specialty, Bud dug deep into the data to figure out exactly what’s happening in the gold futures market—who’s buying, who’s selling, and why. Read on to learn what he discovered about this controversial topic.last_img


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first_imgIn This Issue. * .8% of the 2.6% GDP was ACA. * Currencies try again to rally. * China to widen trading band? * Yellow means go faster! And Now. Today’s A Pfennig For Your Thoughts. 4th QTR U.S. GDP Disappoints! Good Day!…  And a Marvelous Monday to you!  And Welcome to February!  Pitchers and catchers report in a couple of weeks. ? The Beatles greet me this morning with She Loves You. Admit it, you love that song, yeah, yeah, yeah, yeah. Well, did you watch the Super Bowl last night? I tried. But I was in one of those “spells”, and I actually threw in the towel with 5 minutes remaining. As I had told you, and became quite obvious, I really didn’t care who won the game, and I dislike both teams. When I wrote that a couple of weeks ago, I had a Seahawks fan rip me and say that he hoped the Rams left St. Louis that I deserved that. Whoa there partner! Them’s fightin’ words! Well, looky there! The first estimate of 4th QTR GDP here in the U.S. printed at 2.6% last Friday! WOW! What a drop from the trumped up 5% 3rd QTR print.  But, the kicker here folks, is that if you recall, the 3rd QTR didn’t start out at 5%, in fact the previous estimate before the final revision was 3.9%… So, there will be a couple more “revisions” before we finally put to bed the 4th QTR GDP, and by the time we do so, it will be very stale data.  And I’m sure that the book cookers will do their best to meet the President’s call for a strong 4th QTR GDP.  But for now, 2.6% is a HUGE drop from 5%, and to me, it probably represents pretty close to what it should be.  I had told you last Friday morning that I thought if the beans were all counted correctly before “adjustments” 4th QTR GDP would print below 3%…  So, now that it did print below 3%, my mind is racing with all the questions about how many “adjustments” were made just to get it to 2.6%?  And is this the beginning of the problems that I’ve been talking about for the economy without stimulus? And according to John Williams over at shadowstats.com, at least .8% of that 2.6% was a result of the ACA.  So, not only did we stuff the ballot box of GDP reports last year by adding R&D, and other stuff to the calc, but we also added ACA. And the fun never stops boys and girls! Fun? You call this fun, Chuck? Well, not actually, I was being facetious. Oh, I see now, said the blind man as he spit into the wind, it’s all coming back to me now. So, when the 4th QTR GDP report printed on Friday, all the rate hike campers b’d and moaned, and it appeared that they had left their rate hike cake out in the rain. and I don’t think I can take it, because it took so long to bake it, and I’ll never have that recipe again.  And for those of you thinking I’ve lost my mind. quoting lyrics by Donna Summer, I’m not. I go back to the original. Richard Harris. So, there!   But, the rate hike campers took their bats and balls and went home, leaving the dollar to deal with everything on its own. And when the dollar has its accessories stripped away, it doesn’t look so good. on a funny note, I had a friend, send me a YouTube of an old guy singing a song called: I don’t look good naked anymore. That’s the song for the dollar folks! But the biggest surprise on Friday came when the price of Oil started rallying, and when the day finished the price of Oil had risen to above $50, a more than $5 move in one day! All the stories that attempted to explain this move pointed to the number of Oil rigs that had closed up the previous week which showed that the number of operating rigs was at a 3 -year low now, as the rig count dropped 7% the previous week.  I’ve been told by people associated with Oil in some capacity that this rig count isn’t that big a deal, but I’ve got to say that it has to have something to do with production, because has rigs close, they certainly aren’t producing any longer!  I don’t know where this will go, folks, but to me, it appears to be the beginning of the end. So, the currencies are attempting to rally this morning. The euro is up ½-cent, the Aussie dollar is up about 1/3rd of a cent, and so on.. But Gold is down again this morning sitting on a $7 loss right now. I’ve got some more on physical Gold in Asia later this morning, so I won’t spoil your appetite for that now, except to say the buying, producing and hoarding of Gold in the East just keeps gaining momentum. Other stuff that’s dropping includes Treasury yields. The “bond boys”  sure didn’t like the color of the GDP report last Friday, and said so by dropping yields. The yield on the 10-year Treasury is 1.67%, just to point out on point on the yield curve.. 1.67%, that’s less than even the stupid CPI says inflation is running. So. there you go. back up the truck, buy some 10-year Treasuries and start out in the red. And if yields rise anytime in the next 10-years, you’ll remain in the red. OOOOHHHH, Daddy, can I have some, please, I’ll be a good boy, I’ll go to church, and open the car door for mom, please, oh please? Greece is attempting to mend the bridges they burned during the election process. The Prime Minister and Finance Minister will be touring Europe and having meetings with key people in an attempt to gain support for their plans to come up with a new deal for creditors. Well the PM and FM had better arrive bearing gifts, because they really ticked off the countries that have lent them money the past few years. So, this is what it’s like. Someone in your family borrows money from you.  And they agree to the repayment terms, but then things get tight, and they no longer want to honor those repayment terms, so they go about talking bad about them to all their friends and it all gets back to you. And then the family member comes back to you, all nicey-nicey,  wanting to talk about a new deal.  If I were an European Central Bank (ECB) or Bundesbank (German Central Bank) member, I would tell the PM & FM to go to hello operator, give me number 9, if you don’t connect me, I’ll kick you in the behind the refrigerator was a piece of glass, and so on. I think you get the picture! Speaking of debts.I found this in my weekend reading. The White House will be seeking $561 billion from Congress to run the Pentagon in 2016 – its largest budget ever. However, a research and advocacy director told RT that the budget is closer to $1 trillion, and has been for several administrations. And why wouldn’t we believe what the advocates say? It was just 10 days ago that the President called for an end to “mindless austerity” and called for a surge in government spending, and then actually asked Congress to end the sequestration agreed upon four years ago.   I wondered why this request was made at the time that it was, and now I know! In addition, riddle me this Batman. The U.S. says that their deficit last year was only $560-something Billion. But if you look at the U.S. Debt Clock, it shows that in that same period (actually 13 months) we added $1 Trillion to the National Debt. So, how do they do that? How does $560 Billion turn into $1 Trillion? Oh, that’s right, how could I forget? There are all those “off budget” things that get accounted for in a different room, that’s all smoky, and the accountants all wear green shaded visors, and sleeve protectors, and the adding machine tape is running all over the floor. That’s how! But doesn’t that just tick you off just a bit? They throw a ticker-tape parade in celebration that the Budget Deficit last year wasn’t $1 Trillion, the dollar rallies, and people dance in the street, but in reality, it was the same-o, same-o. But Shhhhhh,  we don’t want to wake up the baby. Well, take me away from this discussion before I begin to yell at the walls, and here in the condo that would not be good for the other people in the condo! Well, the latest IMF Futures Position report from the previous week printed on Friday. And the extreme long position of dollars saw a reduction of 15,000 contracts, but still is quite large at 375,000.  However, the non-dollar currencies remained all with net short positions, which leads me to believe that dollar positions were being sold to buy Gold. But that was the previous week, and not last week, it will be interesting to see the positions report this week for last week when Gold slipped once again. One of the really disappointing currencies in the last 10 days has been the Swiss franc. After going on a moon shot after the franc was untied from the euro, the franc has lost ground on what seems like a daily basis. I guess the “safe haven” status for the franc has either lost luster or, the markets are feeling like everything in the world is copasetic.  It’s been a long time since I used that word, copasetic. My friend, Preston, who was the drummer in our band that traveled the country, used to say that word for everything. Hey Preston, want to stop and get a soda? Hey, it’s copasetic. would be the answer, and his answer to just about everything, so you can see why it’s been a while since I used it! HA! But seriously. what’s up with the markets anyway? Have they gone soft on us? Well, actually I think they have, they have fallen into the trap that the Central Banks set for them, and now the markets are afraid of the Central Banks and their ability to move markets against them. Central Banks rule the world! Can you see them wringing their hands together, and laughing that Doctor Evil laugh, and repeating, We rule the world, we rule the world?   The Chinese renminbi / yuan saw a weakening overnight by the Peoples Bank of China (PBOC).  I was doing some reading this past weekend. By the way, I’m reading a new book, titled:  Confessions of an Economic Hit Man.  I’m only about 1/3rd of my way through the book, but brother let me tell you, it’s good stuff! And a true story to boot!  OK.. back to our regularly scheduled programming.  The stuff I was also reading was about China, and the next steps for the renminbi. And of all the things that were talked about, the only one I saw that made sense was the widening of the trading band for the renminbi, which currently stands at +/-2%…  The band was last widened from +/-1% in March 2014. and before that it was April 2012 that the band was widened from +/-.5%, and before that 2007 when they widened it from +/-.3%..  So, I think it would be the next step.  Of course, widening the band doesn’t turn all the green lights on for renminbi appreciation. notice it does say + or –  and in 2014, it was a case of both! But that doesn’t take away from the plans for the renminbi going forward, which I still maintain is taking away the reserve status from the dollar, and propelling the renminbi to such status. Just to be fair and balanced. James Rickards, doesn’t agree with that idea, and instead he has called for a collapse of the Financial system, at which time countries will created a new Gold backed currency.  As crazy as I sound sometimes, and have been called gloom and doom, I can’t get myself to be that gloom and doom. The U.S. Data Cupboard today, has two of my faves data prints. Personal Income & Spending from December. We’ll also see the ISM Manufacturing Data for January.. Recall that the December ISM index number was weaker than it had been in November, and was a surprise to the markets. So, saying that, I come to the realization that “they” can’t let that happen again! And Gold. Well, I promised you something above on Physical Gold and so here we go! This is from Bullionstar.com and of course is the research of Koos Jansen. “As I wrote last time on data from the Shanghai Gold Exchange (SGE), in week 2 of 2015 withdrawals from the vaults of the SGE (that equal Chinese wholesale demand) came in extremely high at 70 tonnes; the third highest amount ever. In week 3 (January 19 – 23), though, the Chinese withdrew even more at 71 tonnes, up 0.89 % w/w, and a new third highest amount ever. Year to date 202 tonnes have been withdrawn from the SGE vaults, up 15 % y/y. Like last week, this was happening while the price of gold was rising sharply, staggering numbers. It’s still a mystery why mainstream media are not tracking weekly SGE withdrawals. I’ve read all over the news that Russia’s central bank has added 152 tonnes of gold in total to its reserves in 2014. In perspective, this is approximately the same amount of gold China has imported in the first three weeks of 2015. In my post China Continues To Drain Global Gold Inventory I have, once again, pointed out that import numbers derived from SGE withdrawals are for 95 % covered by export from the UK, Switzerland, Hong Kong and the US. These countries disclose only non-monetary gold trade, which support my assumption PBOC purchases are an invisible side show from public gold trade numbers and SGE withdrawals.” Alrighty then. Now it’s time to go to the For What’s It’s Worth section for today. And today, I have something from my daily perusals of zerohedge.com, and can be read there in its entirety by clicking here: http://www.zerohedge.com/news/2015-01-30/what-happens-when-markets-realize  To set this up, it’s Charles Plosser, head of the Philly Fed speaking, pay close attention here folks.. “One of the things I’ve tried to argue is look, if we believe that monetary policy is doing what we say it’s doing and depressing real interest rates and goosing the economy and we’re in some sense distorting what might be the normal market outcomes at some point, we’re going to have to stop doing it. At some point the pressure is going to be too great. The market forces are going to overwhelm us. We’re not going to be able to hold the line anymore. And then you get that rapid snap back in premiums as the market realizes that central banks can’t do this forever. And that’s going to cause volatility and disruption.” Chuck again. WOW! A Fed member actually talking about how the Fed has distorted normal market outcomes! For once you get to hear from a Fed member, and not just me, talking and ranting about this stuff, and to this point sounding like the boy who cried wolf. To recap. The 4th QTR GDP first reading was just 2.6%, well below the expectations for a +3% print. And .8% of that 2.6% came from the ACA, so the fun just keeps coming for us!  The currencies tried to rally on the weaker GDP report, but fizzled out on Friday, and they have picked up the attempt to rally again this morning. Greece leaders are touring Europe in attempt to repair the bridges they burned during the election process.  Chuck questions the accounting of the Budget Deficit, and Gold gets sold again. what’s going on? Before I go to the currency roundup today, I wanted to take a minute, and talk about the loss of a baseball legend. Well, they laid to rest one of the top 100 ball players of the last 100 years on Saturday. RIP Ernie Banks, Mr. Cub. I really only saw Ernie Banks play ball at the end of his career, but my dad used to tell me about his ability, which was always a strong sign of respect when someone praised a ball player on a different team than the Cardinals, and add to that a Cub!  He was always recognized by that great smile, and his slogan, “let’s play two”.  I had a Cub fan send me a note last week when it was announced that Ernie Banks had died, and he asked me if I was such a diehard Cardinals fan that I couldn’t bring myself to talk about the passing of Ernie Banks.  WOW, I thought. I don’t think that would ever get in the way, and this is to prove it!  My friend, and retirement guru, Dennis Miller, is a lifelong Cub fan, and he tells me that Ernie Banks the Stan Musial of Chicago. Now that’s high praise!  So, RIP Mr. Cub. Currencies today 2/1/15.: American Style: A$ .7795, kiwi .7275, C$ .7885, euro 1.1340, sterling 1.5015, Swiss $1.0750, . European Style: rand 11.5755, krone 7.7540, SEK 8.2725, forint 274.20, zloty 3.6875, koruna 24.5005, RUB 69.23, yen 117.60, sing 1.3525, HKD 7.7540, INR 61.79, China 6.1385, pesos 14.94, BRL 2.6770, Dollar Index 94.76, Oil $50.06, 10-year 1.67%, Silver $17.15, Platinum $1,230.50, Palladium $777.30, and Gold. $1,272.14 That’s it for today. Quite full-o-words this morning, eh? Well, I was down and out in Beverly Hills most of the weekend, but got a good night’s sleep last night, so all is back to normal this morning! YAHOO! Little Feat is playing: Dixie Chicken on the iPod right now. Love to sing along with that song! Our Blues won in Washington D.C. yesterday, and I got to watch the game! NBC Sports Network aired the game, and just by chance I found that channel that I didn’t know I had! The TV Guide on the TV only goes to channel 98, but this channel was 730!  I guess it pays to just keep clicking “next” until the end, eh? The Blues have picked up where they left off before the All-Star Game break, and that included them playing their best hockey of the year! Let’s hope they don’t peek too soon, like they normally do! I did face time with my grandson, Braden the other day. He cracks me up. I taught him last year, that green is go, red is stop and yellow means “go faster”! And he told Kathy that the other day, as the light turned yellow as she was driving through the intersection. “Mimi, yellow means go faster!”  HA! Hey! Isn’t that my job as his grandfather, to teach him things? Cracks me UP!  Well, we had a plethora of birthdays last week, I hope everyone had a grand day.  And with that, I need to get going. I have a very important date! (not really, but the sun is out!)  I hope you have a Marvelous Monday! Chuck Butler Managing Director EverBank Global Marketslast_img read more


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first_imgSo far, the federal government has given more than half a million dollars to assist local tornado victims in Guilford and Rockingham Counties.It’s been nearly two months since an EF-2 tornado ripped through Greensboro, destroying homes, businesses and schools. One person was killed. The storm also ravaged communities in Rockingham County. According to the Federal Emergency Management Agency, 1,169 people in Guilford County have registered for federal assistance. In Rockingham County the number is 90. Roger Ingram with FEMA says the money will help victims get a fresh start.“It will help a person with rental assistance and repairs to their homes. It can help with furniture, automobile repair and other items,” says Ingram. “It’s extremely important that they talk with their insurance company and find out exactly what coverage they will get from them. Once they’ve settled with their insurance company, if they are underinsured or uninsured, they can come back to FEMA with their settlement letter and there may be other assistance available for that individual.”FEMA also partners with the U.S. Small Business Administration to help people recover from disaster situations. The agency offers low interest rate loans. SBA officials say as of this week, they’ve approved more than $400,000 to help individuals and local business owners affected by the storm.“We have received 741 home referrals from FEMA and 143 business referrals,” says A.J. Velazquez, a public affairs specialist with the Small Business Administration Office of Disaster Assistance.FEMA officials say individuals shouldn’t wait to apply for federal aid. The registration deadline for that is July 9th.Ingram says victims can receive help with the process and SBA loan application at the Disaster Recovery Center located on Maple Street in Greensboro.Follow WFDD’s Keri Brown on Twitter @kerib_newslast_img read more


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first_img Zynga, the 7-year-old social gaming company behind the ubiquitous Words with Friends and Farmville, announced the layoffs of 314 employees this week, which amounts to about 15 percent of its staff. The company hopes the cuts will save them up to $35 million this year. Zynga currently employs 2,100 people, down from 3,300 in 2012.Related: Zynga Layoffs: What Happens When Startups Grow Too Fast CEO Don Mattrick also announced the $527 million purchase (in both cash and equity) of interactive company NaturalMotion, Zynga’s largest acquisition to date.  The company bought OMGPOP, the company behind the once-viral app Draw Something, for $200 million in 2012.NaturalMotion was founded in 2001 and is based out of Oxford, England. Zynga will be gaining 260 new employees from the acquisition. It’s the maker of mobile games such as Clumsy Ninja and My Horse. The company has also developed animation technologies called Euphoria and Morpheme that have been used in popular games like Grand Theft Auto IV and BioShock Infinite, respectively.Related: No Games: Zynga’s New CEO Shakes Up ManagementZynga has been navigating choppy waters for some time. Last summer, the company axed 500 jobs and founder Mark Pincus was replaced as CEO by Mattrick, the former head of Microsoft’s Xbox division.While there was a time when it seemed almost impossible to scroll through Facebook without seeing someone’s purchase of virtual livestock, King.com, the creator of Candy Crush Saga is currently the No. 1 maker of games for the site. With the purchase of NaturalMotion, Zynga is aiming to be major player in the mobile market. Related: The Keys to Candy Crush’s Success 2 min read Staff Writer. Covers leadership, media, technology and culture. Nina Zipkin Apply Now » Entrepreneur Staff Zynga Makes Its Biggest Buy Yet, Announces Fresh Round of Layoffs The only list that measures privately-held company performance across multiple dimensions—not just revenue.center_img –shares Technology Add to Queue 2019 Entrepreneur 360 List Next Article January 31, 2014last_img read more


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first_imgReviewed by James Ives, M.Psych. (Editor)Oct 17 2018A team from the University of Pennsylvania, Children’s Hospital of Philadelphia, and University of Wisconsin–Madison are launching a project to develop new strategies for treating vision disorders using cells implanted in the retina.The work is one of five initiatives newly funded by the National Institutes of Health’s National Eye Institute (NEI) Audacious Goals Initiative. The program’s mission is to accelerate the development of regenerative medicine treatments for blindness. To that end, NEI is devoting $30 million for five years to five multidisciplinary teams around the country. The Penn, CHOP, and UW-led team will receive $6.9 million to support their research into restoring areas of the retina damaged due to blinding diseases.The principal investigators are John Wolfe of Penn’s School of Veterinary Medicine and the Children’s Hospital of Philadelphia, William Beltran of Penn Vet, and David Gamm of the University of Wisconsin-Madison. Members of this group have used gene therapy approaches in the past to address genetic blinding diseases, with many successes. To replace or correct faulty genes, however, these treatments require living cells in the retina. At later stages of some blinding diseases, many if not most photoreceptor cells have perished. The group’s hope is that the cell-based therapies they’re creating may enable those with vision loss to regain sight even when key vision cells have already died.Related StoriesMathematical model helps quantify metastatic cell behaviorExciting study shows how centrioles center the process of cell divisionAbcam Acquire Off-The-Shelf Diploid Library of Over 2,800 Knockout Cell Lines”We will be generating specialized retinal cells in a dish from reprogrammed adult stem cells and then transplanting them into the retina,” says Wolfe. “Our work is going to be directed toward developing the right kind of cells, working on methods to transplant them into the retina, and examining the neural connections that form to see how the implanted cells are functioning. It’s the translational component of the research we’ve all been doing for a long time.”Wolfe and his lab will be isolating and growing light-sensing photoreceptor cells, derived from stem cells from blind dogs, in collaboration with Gamm and colleagues, who have used embryonic and induced pluripotent stem cells in experimental cell-based therapies in human disease models. Beltran and colleagues, including Gustavo Aguirre, Karina, Guziewicz, and Oliver Garden from Penn Vet and Geoffrey Aguirre from Penn’s Perelman School of Medicine, will be contributing expertise from studying and developing gene therapies for a variety of vision disorders in dogs, including retinitis pigmentosa, the canine version of which recapitulates many characteristics of human disease.New disease models will enable researchers to test novel regenerative therapies and help transition them to the clinic. “Models that recapitulate human disease are essential to predicting the success of new therapies in humans. These audacious projects will be pivotal in our efforts to translate the latest science advances into new treatments for vision loss and blindness,” said NEI Director Paul A. Sieving. Source:https://penntoday.upenn.edu/news/multidisciplinary-team-develop-stem-cell-based-approaches-restore-visionlast_img read more